Russian scientists have named the biomarkers a long

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Veterans have helped scientists Southern Urals State University identify biological indicators that signal whether people have post-traumatic stress disorder or sensitivity to it. The search results are published in the Journal of Psychiatric research (Q1) top-notch scientific journal.

In their research on the study of post-traumatic stress disorder, the representatives of the SUSU School of Medical Biology have reached a new level. Previously, they used an experimental method of stimulate post-traumatic stress disorder in rats and tracking changes in their body. Now the global scientific community has been presented with the results of the clinical study.

Work began in 2016. More than a hundred people participated: patients of the Chelyabinsk Regional Clinical Therapeutic Hospital for Veterans and combat action participants who had not been diagnosed with disease. Scientists conducted clinical interviews with each participant and used diagnostic scales to assess the severity of the disease. At the same time, blood samples were taken to compare changes in the body and determine markers of PTSD.

“All of the research participants were separated from the traumatic events by a long interval of time: at least ten years. We were able to find that even after a long time, the levels of cortisol and gamma-aminobutyric acid differed from the reference values. Gamma-aminobutyric acid appeared to be the most sensitive indicator, it can be considered a marker of long-lasting PTSD. A low acid level has been shown in a group of people sensitive to stress, ”said Doctor of Science (Biology), Director of the SUSU School of Medical Biology Vadim Tseylikman.

Everyone who had been through traumatic events had high levels of cortisol. It was this discovery that allowed researchers to prove once again that despite extensive experimental studies of PTSD, the structure of the disease is not homogeneous.

“Thanks to this research, carried out by the Laboratory for Molecular Genetic Studies of Health and Well-being led by Inna Feklicheva and our colleagues from the Netherlands, Dr Marco Boks and Dr Ron de Kloet, we are now able to predict whether a person would be susceptible to PTSD or resistant to the disease after combat stress judged by changes in blood plasma, ”added Vadim Tseylikman.

The international team of scientists intends to continue the work and now consider changes in the genomic profile of people who have experienced traumatic events. The remaining blood samples will be examined. the SUSU consortium partner, the Institute of Cytology and Genetics of the Siberian branch of the Russian Academy of Sciences, will be involved in this work.

Thanks to the research work of the School of Medical Biology, SUSU entered the RUR world ranking in the field of medical sciences and was ranked in the top ten of Russian universities.

The Southern Urals State University (SUSU) is a university of digital transformations, where innovative research is carried out in most of the priority areas of scientific and technological development. In accordance with the strategy of scientific and technological development of the Russian Federation, the university focuses on the development of large interdisciplinary scientific projects in the fields of digital industry, materials science and ecology. During the Year of Science and Technology, SUSU became the winner of the Priority-2030 program competition. The university acts as the regional project office of the world-class Ural Interregional Research and Education Center (UIREC).


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